The Volunteers beat the Gamecocks 72-53, keeping USC winless in Thompson-Boling Arena since 2002.
The Volunteers (15-8, 6-4 SEC) led by 23 at the half.
South Carolina had one bright spot during the game when they went on a 10-0 run in the second half.
Freshman Sindarious Thornwell lead the Gamecocks with 15 points.
