The Tigers handed Louisville its first three-game sweep since joining the ACC in 2015 and its first three-game sweep since 2011.
With the win, the Tigers advance to face Marshall on Thursday, May 6 at WakeMed Field in Cary, N.C.
Tiger starter Keyshawn Askew pitched a career-high-tying 6.2 innings, allowing seven hits, four runs (two earned) and no walks with a career-high 10 strikeouts.
A historic draft for Clemson that started with the first No. 1 pick in program history on Thursday concluded Saturday with the fifth-round selection of Cornell Powell by the Kansas City Chiefs with the No. 181 overall pick.
This year’s draft marks the third straight year that Clemson has produced four selections over the first three rounds.
Clemson will advance to the Sweet Sixteen for the first time since the 2016 season.
The Tigers, who took a 1-0 lead in the series, improved to 19-18 overall and 13-12 in the ACC.
The win was head coach Monte Lee’s 200th at Clemson.
The decision comes after revised financial projections show the impacts of COVID-19, while significant, did not harm the University in as drastic a way as anticipated.
The victory extended the Tigers’ winning streak to 13 games as Clemson improved to 20-0 on the season when leading after the first.